Clinical Trial Comparing Efficacy and Safety of Ornidazole 1% and Povidone Iodine 5% Fixed Dose Combination Ointment with Povidone Iodine 5% Formulation and Ornidazole 1% Formulation for Prevention or Treatment of Surgical Wounds.

Aim: This trial is undertaken to evaluate the efficacy and safety of this FDC ointment for post-surgical patient management. This multi-centre, prospective, randomized, comparative, open-labeled, three-arm parallel group study involving 180 patients was conducted in patients with surgical wound. The trial was conducted at 2 centres and had 90 patients completed at each center. Methods: Patients were in randomized in three groups, to receive either the study formulation of Ornidazole 1% - Povidone iodine 5% FDC ointment (Group I ) or Povidone iodine 5% Ointment (Group II) or Ornidazole 1% Ointment (Group III). These ointments were applied for post surgical wound care. Dressing was done twice daily till the discharge of patients (Day 5-7). Patients were asked to use respective ointment for wound dressings after discharge. The patients were assessed for clinical wound improvement by using the Bates Jensen Wound Assessment Tool (BWATS). General and systemic examination was done at every visit of the patient. Results: Reduction in wound size was significant in all three groups from day 1 onwards. In group I exudates amount improved significantly from day 5 as compared to day 3, in Group II and Group III the improvement was from Day 8 onwards as compared to day 5. Peripheral tissue edema and Peripheral Tissue Induration improved in Group I and as compared to baseline. Epithelialization was statistically better in Group I and Group II from day 1 compared to baseline and in Group III it improved from day 5. No adverse event were seen in any of the groups. Conclusion: We concluded that the combination was better as compared to each individual drug in prevention of wound infection and promoting wound healing.

Amebiasis in the newborn.

Infestation with Entamoeba histolytica is especially common in areas with low socioeconomic status. Extra intestinal invasive involvement is more frequent in young children with significant mortality. This disease is rarely reported in the newborns. This 19-day-old newborn who was infected with orally given surgar solution is presented. He was successfully treated with omidazole.

Naegleria meningitis: a rare survival.

Acute amebic meningoencephalitis caused by free-living amebae naegleria fowleri is extremely rare and uniformly fatal with only seven survivals reported till date. An interesting case of naegleria meningitis diagnosed by wet mount cytology of cerebrospinal fluid (CSF) and treated with amphoterecin B, rifampicin and ornidazole with complete recovery is presented. In cases of suspected pyogenic meningitis, if CSF staining, antigen detection or culture is negative for bacteria, a wet mount cytology of CSF for naegleria is suggested. Early treatment with amphoterecin B and rifampicin may improve survival.

Preparación preoperatoria en cirugía colorrectal electiva : una evaluación prospectiva / Pre-surgery preparation in elective colorectal surgery : a prospective evaluation

Si bien existe acuerdo en la necesidad de la preparación preoperatoria para la cirugía colorrectal electiva, los métodos utilizados tanto en la limpieza mecánica como en la antibiótico profilaxis varían sustancialmente entre los diferentes centros consultados. El objetivo de la presente comunicación fue determinar la efectividad y tolerancia de un protocolo de limpieza mecánica con 4 litros de solución de polietilenglicol (PEG) y antibiótico profilaxis con monodosis de 1 gr. de ornidazol y 750 mg. de ciprofloxacina administradas por vía oral 12 y 2 hs. antes de la cirugía respectivamente. Se evaluó un total de 100 pacientes (55 del sexo masculino) sometidos a cirugía electiva por adenocarcinoma colorrectal. La edad promedio fue de 64,5 (34-84 años). El 81 por ciento completó la ingesta de 3 o más litros, siendo el volumen promedio ingerido de 3.6 (1,6-4) litros. Si bien el 74 por ciento de los pacientes consideró la tolerancia como "excelente" o "buena", el 76 por ciento presentó algún tipo de efecto adverso: naúseas (48 por ciento), plenitud (17 por ciento), cólicos (7 por ciento), vómitos (3 por ciento), otros (4 por ciento). De acuerdo a la apreciación del cirujano durante la cirugía, la limpieza colónica fue clasificada como "adecuada" en el 89,4 por ciento de los casos. El índice de infección de herida fue del 3 por ciento. En 3 casos se produjo dehiscencia anastomótica. Sólo un paciente desarrolló sepsis peritoneal debiendo ser reoperado. La mortalidad postoperatoria fue nula. En base a estos resultados se concluye que la solución de PEG es efectiva y segura para la limpieza colónica. Sin embargo, un alto porcentaje de pacientes presenta, aunque leve, algún tipo de efecto adverso. La monodosis preoperatoria de ciprofloxacina más ornidazol administradas por vía oral fue altamente eficaz para evitar la infección de herida.

Preparación anterógrada y profilaxis antibiótica con dosis única en cirugía colorrectal electiva / Anterograde preparation and antibiotic prophylaxis with a single dose in elective colorectal surgery

Cincuenta y nueve pacientes sometidos a cirugía colorrectal electiva recibieron preparación de colon por vía anterógrada y profilaxis antibiótica en dosis única con ceftriaxona y ornidazol. La preparación utilizada fue bien tolerada, obteniendo una adecuada limpieza del lumen intestinal y minimizando las alteraciones hidroelectrolíticas y del equilibrio ácido-base. No hubo sepsis ni complicaciones sépticas graves intraabdominales.

Ornidazol en el tratamiento de la amibiasis intestinal / Ornidazol in the therapy of intestinal amebiasis

Para conocer la actividad terapéutica del Ornidazol (Tiberal) en la amibiasis intestinal, se administró el producto en 40 pacientes divididos en dos grupos (I y II) de 26 y 14 casos a la dosis de 500 mgrs. cada 12 horas por 7 y 5 días respectivamente. Siete días después de finalizado el tratamiento se practicó control coproparasitoscópico mediante examen directo y por concentración. El control se logró practicar en 20 pacientes del grupo I y en 11 del grupo II con porcentajes de curación de 85.0 y 90.90% respectivamente; en total en ambos grupos hubo curación parasitológica en el 87.0%. Se comparan los resultados con los reportados por otros autores y se concluye que en efecto el Ornidazol es un imidaólico útil en el tratamiento de la Amibiasis intestinal

Treatment of giardiasis in children with quinacrine, metronidazole, tinidazole and ornidazole.

One hundred and twenty four children with symptomatic and parasitologically confirmed giardiasis were treated in a comparative trial. The dosage of antigiardia drug was adjusted to the body surface area of the patients from the adult basic dosage as 100 mg of quinacrine t.i.d. for 5 days, 200 mg of metronidazole t.i.d. for 7 days, 2 gm of metronidazole once, 2 gm of tinidazole once or 2 gm of ornidazole once. They were hospitalized for follow-up for 30 days. The parasitological follow-up consisted of daily examination of stool specimens. Reinfections were unlikely. The rates of success were: a 5-day course of quinacrine, cured all of them, 20 patients; a 7-day course of metronidazole, 12 of 20; metronidazole, single dose, 11 of 21; tinidazole, single dose, 18 of 21; ornidazole, single dose, 21 of 22; placebo, none of 20. After a single dose, 5 patients had transient elevation of transaminases, one patient in each of metronidazole and tinidazole group 3 patients in ornidazole group. A 5-day course of quinacrine gave excellent result but the drug is not widely marketed. Ornidazole or tinidazole were more effective, both of them were recommended as a drug of choice as single dose therapy, however transient increase of transaminases may occur in some cases.